Applied molecular biology Essay Example | Topics and Well Written Essays - 500 words

Applied molecular biology - Essay ExampleOne of the subclasses was germinal-center B-cell-like DLBCL which showed an brass pattern the same as the mature germinal-center B-cells and portended a more favorable prognosis with a 60% five-year survival rate. Besides that, two other DLBCL subclasses, these are, type-3 DLBCL and excited B-cell-like DLBCL, presented much less favorable prognoses with a 35% five-year survival rate.From all these and the researches, it may be possible to determine the patients that might benefit from more bellicose therapies such as chemotherapy regimens or bone marrow transplants when DLBCL is diagnosed. HD DNA microarray studies have highlighted molecular pathways that are important in cancer subclasses. Example, researchers have observed that some(prenominal) genes in the activated B-cell subclass of DLBCL were downstream targets of the NFkB transcription factor. They proved that NFkB activity is higher in this DLBCL subtype thereby suggesting that drug s targeting the NFkB may be impelling in the treatment of these tumors. (Cain, 2011)broker expression profiling of tumor specimens may be useful in the pre-selection of patients who may benefit from drug treatment. It can also be used in examining gene expression profiles of cancers following chemotherapy so as to determine whether the tumors are responding to treatment. In this method, detailed patient-specific molecular information would be used to predict an effective therapy. (Schwab,